Enzymes and Inhibitors
New England Biolabs, Inc. α1-2 Fucosidase - 1000 units
a1-2 Fucosidase is a highly specific exoglycosidase that catalyzes the hydrolysis of linear 1-2 linked fucose residues from oligosaccharides
New England Biolabs, Inc. β1-3 Galactosidase - 500 units
b1-3 Galactosidase is a highly specific exoglycosidase that catalyzes the hydrolysis of 1-3 and, at a much lower rate, 1-6 linked galactose residues from oligosaccharides.
New England Biolabs, Inc. α1-6 Mannosidase - 800 units
a1-6 Mannosidase is a highly specific exoglycosidase that removes unbranched a1-6 linked mannose residues from oligosaccharides. When used in conjunction with a1-2,3 Mannosidase, the a1-6 Mannosidase will cleave a1-6 mannose residues from branched carbohydrate substrates.
New England Biolabs, Inc. dam Methyltransferase – 500 units
dam Methyltransferase modifies the adenine residue (N6) of the sequence GATC.
New England Biolabs, Inc. USER® Enzyme – 50 units
USER (Uracil-Specific Excision Reagent) Enzyme generates a single nucleotide gap at the location of a uracil. USER Enzyme is a mixture of Uracil DNA glycosylase (UDG) and the DNA glycosylase-lyase Endonuclease VIII. UDG catalyses the excision of a uracil base, forming an abasic (apyrimidinic) site while leaving the phosphodiester backbone intact. The lyase activity of Endonuclease VIII breaks the phosphodiester backbone at the 3 and 5 sides of the abasic site so that base-free deoxyribose is released.Applications of USER include:
- Directional RNA Seq
- NEBNext adaptor cleavage
- USER cloning
New England Biolabs, Inc. USER® Enzyme – 250 units
USER (Uracil-Specific Excision Reagent) Enzyme generates a single nucleotide gap at the location of a uracil. USER Enzyme is a mixture of Uracil DNA glycosylase (UDG) and the DNA glycosylase-lyase Endonuclease VIII. UDG catalyses the excision of a uracil base, forming an abasic (apyrimidinic) site while leaving the phosphodiester backbone intact. The lyase activity of Endonuclease VIII breaks the phosphodiester backbone at the 3 and 5 sides of the abasic site so that base-free deoxyribose is released.Applications of USER include:
- Directional RNA Seq
- NEBNext adaptor cleavage
- USER cloning
Selleck Chemical LLC Cabozantinib (BMS-907351) 200mg 849217-68-1 XL184
Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3?/NF-?B signaling pathway. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Echelon Biosciences Research Labs a-Secretase Substrate II , Fluorogenic - 1 mg,
CBR 6551 / a-Secretase Substrate II , Fluorogenic - 1mg , Ac-Arg-Glu(EDANS)-Val-His-His-Gln-Lys-Leu-Val-Phe-Lys(Dabcyl)-Arg-OH Category/Application: Alzheimer's This item is non returnable
Echelon Biosciences Research Labs DRONC Substrate - 5 mg,
DRONC Substrate - 5mg , Ac-Thr-Gln-Thr-Asp-AFC Category/Application: Enzyme Substrates This item is non returnable
Enzo Life Sciences Matrix metalloproteinase (MMP) multipack-1 (1 Kit)
The MMP multipack-1 contains 10µg each of five highly active recombinant MMP catalytic domains: MMP-1, MMP-2, MMP-8, MMP-9, and MMP-13. Contents: Contains 10µg of each enzyme, provided in a screw-cap microfuge tube. MMP-1 (catalytic domain) (human), (recombinant) (Prod. No. BML-SE180), MMP-2 (catalytic domain) (human), (recombinant) (Prod. No. BML-SE237), MMP-8 (catalytic domain) (human), (recombinant) (Prod. No. BML-SE255), MMP-9 (catalytic domain) (human), (recombinant) (Prod. No. BML-SE360), MMP-13 (catalytic domain) (human), (recombinant) (Prod. N. BML-S24). Application: FUNC, HTS. Long Term Storage: -80°C
New England Biolabs, Inc. β1-3,4 Galactosidase - 400 units
b1-3,4 Galactosidase is an exoglycosidase that catalyzes the hydrolysis of terminal, non-reducing b1-3 and b1-4-linked galactose residues from oligosaccharides.
Biotium NucView 488 Caspase-3 Substrate, 1mM in 1X PBS
NucView Caspase-3 Substrates are novel fluorogenic substrates for real-time or endpoint detection of apoptosis in live cells. The non-toxic, no-wash substrates do not inhibit caspase-3 unlike other caspase substrates or FLICA assays permitting multiday analysis. They consist of a high-affinity DNA dye linked to a DEVD caspase-3 substrate moiety. Initially non-fluorescent, the cell permeable substrate is cleaved by caspase-3 in apoptotic cells and emits fluorescence, for detection of caspase-3 activity and apopototic nuclear morphology. Suitable for flow cytometry, fluorescence microscopy, or live cell imaging systems, staining is compatible with fixation and permeabilization for immunostaining. NucView 488 is validated in over 100 cell types and 200 publications. Available with blue (NucView 405), green (NucView 488), or red (NucView 530) fluorescence, as PBS solutions for DMSO-sensitive cells, and as stand-alone assays or in kits with other apoptosis or necrosis probes.
Cayman Chemical E3 LIgase LIgnd 2 1g
An active metabolite of thalidomide and a PROTAC synthetic intermediate; decreases production of TNF-α induced by TPA in THP-1 cells at 30 µM; completely inhibits the proliferation HUVECs at 333 µM; inhibits VEGF- and FGF2-induced angiogenesis by 14% in a CAM assay in utero at 100 UG/embryo